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Development of New Therapeutic Strategies in Gynecological Cancers in Iran by Utilizing Xenograft Model of Ovarian Adenocarcinoma
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نویسنده
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Mazaheri Zohreh ,Muhammadnejad Samad ,Muhammadnejad Ahad ,Zargarzadeh Moein ,Kazem–Haghighi Maryam ,Oghabian Mohammad Ali ,Tirgari Farrokh ,Amanpour Saeid
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منبع
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journal of family and reproductive health - 2010 - دوره : 4 - شماره : 3 - صفحه:105 -107
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چکیده
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Objective: to evaluate the potentiality of ovcar-3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice.materials and methods: the cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. established tumors were transferred to pathology laboratory to be prepared by h&e staining and immunohistochemical staining with ca125 antibody.results: study of h&e slides showed advanced adenocarcinoma. the ca125 tumor marker was also positive in tumoral tissue. conclusion: established tumors showed excellently the characteristics of ovarian adenocarcinoma. this model can be used to evaluate new treatment strategies.
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کلیدواژه
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Gynecological cancers ,Xenograft model ,Ovarian adenocarcinoma
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آدرس
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tehran university of medical sciences tums, Reproductive Health Research Center, ایران, tehran university of medical sciences tums, Reproductive Health Research Center, ایران, tehran university of medical sciences tums, Reproductive Health Research Center, ایران, tehran university of medical sciences tums, Reproductive Health Research Center, ایران, tehran university of medical sciences tums, Reproductive Health Research Center, ایران, tehran university of medical sciences tums, Research Center for Science and Technology in Medicine, ایران, tehran university of medical sciences tums, Reproductive Health Research Center, ایران, tehran university of medical sciences tums, Cancer Institute, Cancer Research Center, ایران. tehran university of medical sciences tums, Reproductive Health Research Center, ایران
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پست الکترونیکی
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saiedamanpour@yahoo.com
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Authors
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