Effect of Anti Phospholipid Antibodies on in Vitro Fertilization/Intracytoplsmic Sperm Injection Outcome

Objective: the study aimed to determine the relationship between presence of antiphospholipid antibodies (apls) and clinical pregnancy rate in patients undergoing ivf/icsi procedures. materials and methods: this descriptive-analytic study performed on two hundred consecutive women referred for ivf/icsi in vali-e-asr reproductive health research center. serum levels of apls , anticardiolipin [acl], antiphosphatidic acid [apa], antiphosphatidyl choline [apc] and antiphosphatidylserine [aps] were checked for all patients before starting ivf cycles. apls seropositivity and clinical pregnancy rate were determined. t-test and mann-whitney were used to compare two groups. p value <0.05 was considered significant. results: 23 women (11.5%) were apl positive. twenty nine women of 177 apl seronegative patients (16.4%) became pregnant while only one of 23 seropositive patients (4.3%) was pregnant. clinical pregnancy rate was not significantly different in two groups. conclusion: although apls were common, these antibodies did not affect the outcome of ivf/icsi procedures. thus screening for apls is not recommended in women undergoing these procedures.