Effect of Flushing the Endometrial Cavity With Follicular Fluid on Implantation Rates in Sub-Fertile Women Undergoing Invitro Fertilization: A Randomized Clinical Trial

Objective: to examine the effectiveness of intrauterine injection of follicular fluid in in vitro fertilization (ivf). materials and methods: a parallel randomized control clinical study was conducted on 110 patients attending al–zahra educational-medical center of tabriz university of medical sciences. female candidates for ivf were categorized into intervention (n = 55) and control (n = 55) groups using randlast software (version 1.2). following an identical protocol of gonadotropin-releasing hormone (gnrh) antagonist stimulating ovulation, in the intervention group a total of 2ml of follicular fluid was injected as intrauterine after the accomplishment of follicular puncture. embryo transfer was carried out after 2-3 days. the rates of implantation, as well as chemical and clinical pregnancy were compared between the two groups. results: there were no significant differences in chemically proven pregnancy (19 in intervention group (34.5%) vs. 23 (41.8%) in control group p = 0.43), or in clinical pregnancy (30.9% vs. 38.2%, respectively p = 0.42), and in implantation rates (11.52 ± 2.57 % (range, 0-66.7) vs 18.79 ± 3.72 % (range, 0-100), respectively). conclusion: injection of follicular fluid into the uterine cavity in candidates for ivf neither improves nor adversely affects the outcome of the therapy.