Benefits of Metformin Combined with Insulin in Children with Type 1 Diabetes Mellitus.

Background: some patients with type 1 diabetes mellitus have not good glycaemic control with ordinary doses of insulin. so applying other treatment modality in addition to insulin and diet therapy could improve glycaemic control.objective: to evaluate whether, in patients with type 1 diabetes mellitus, the addition of metformin to insulin and standard diabetes management result in better glycaemic control and lower insulin dosage .methods: in a clinical trial study 16 children and adolescents with type 1 diabetes with had high insulin intake and hba1c > 8% were participated. hba1c, fbs, 2hpp bg, insulin dosage and bmi were measured and compared at the onset and end of the treatment.results: there were significant differences in hba1c and insulin dosage between the time of 0 of the study and after 4 months of metformin addition therapy. but there were no significant differences between bmi, fbg and 2 h pp bg at the onset of the study and end of it.conclusion: metformin treatment lowered hba1c and decreased insulin dosage in patients with type 1 diabetes in poor metabolic control. long term studies will determine if these improvements are sustained.