the effect of high-intensity interval training on the adiponectin and tnf-α levels of serum and adipose tissues in rats fed with a high-fat diet plus sucrose solution

Background: adipocytokines secreted by adipose tissue are suggested to play a significant role in developing obesity-related complications. on the other hand, regular high-intensity interval training (hiit) has been shown to reduce the risk of metabolic complications in obese subjects. objectives: the effect of hiit was evaluated on serum and adipose tissues (inguinal and retroperitoneal) adiponectin and tnf-α levels in rats fed with a high-fat diet plus sucrose solution (hfds). methods: thirty-two male wistar rats were randomly divided into hfds and standard diet (sd) groups. after 12 weeks, each group was divided into a sedentary group and a hiit group. an hiit program was performed three times/week for eight weeks. inguinal and retroperitoneal adipose tissues and serum were collected to assay adiponectin and tnf-α levels. also, serum glucose and insulin levels, insulin resistance index (homa-ir) were measured. results: hfds significantly increased weight gain, weight of inguinal (p = 0.001) and retroperitoneal fat depots (p < 0.001), and homa-ir (p < 0.001) but reduced serum tnf-α levels (p = 0.011). hiit was able to decrease weight gain and fat mass (p < 0.05) but did not affect inguinal and retroperitoneal fat depots’ adipokines (adiponectin and tnf-α) levels and homa-ir (p > 0.05). conclusions: hiit program can have significant reducing effects on weight gain and fat weights, but it does not effect on circulating and fat depots' adiponectin and tnf-α levels in rats fed a hfds.