investigation of sars-cov-2 ability to pass through the placenta

Context: recently, a new coronavirus (sars-cov-2) as the cause of covid-19 has made a global health crisis and a great challenge. pregnant women and fetuses are among the high-risk groups for covid-19. in this review, we summarize studies regarding sars-cov-2 virus-placenta interactions at the maternal-fetal interface by demonstrating the pathogenicity of the virus and defense methods of the placenta. evidence acquisition: in the present study, a search was done in domestic and international databases including google scholar, web of science, pubmed, and scopus using specific keywords (“coronavirus” or “covid-19” or “sars-cov-2”) and (“fetus” or “placenta”) and (“pregnancy”), limited until august 2020. finally, we reviewed 250 articles. results: generally, the pathogenicity and the life cycle of sars-cov-2 and virus entry and replication methods allow the virus to pass through the placenta, although there are hormonal and immune barriers in the placenta against sars-cov-2, such as placental type interferons. conclusions: the sars-cov-2 can pass through the placenta, but there are defense methods against it.