diurnal corrected qt interval and qt dispersion variation in non-alcoholic cirrhotic patients and healthy control: a case-control study, iran

Background: cirrhosis could lead to a long corrected qtc interval in a subgroup of patients, but there are spare data on its diurnal variation.objectives: the present study aimed to determine the diurnal variation of qt_c interval and its relationship to heart rate and blood pressure variation during 24hour holter-monitoring in non-alcoholic cirrhosis in comparison with the healthy controls. methods: the study population comprised 15 patients with nonalcoholic cirrhosis and 15 healthy subjects, undergoing 24hour electrocardiogram (ecg), heart rate, and blood pressure monitoring. the mean qt interval, mean qt_c, maximum and minimum qt, qt dispersion (qt_disp), heart rate, and mean arterial blood pressure were measured for each person for 24 hours. liver stiffness measurement (lsm) was performed by fibroscan® 502 machine (echosense, paris, france, 5 mhz). the results were demonstrated as percentages and mean ± sd. p value ≤ 0.05 was considered significant. results: mean qt_c was significantly higher in cirrhosis (438 ms) than healthy controls (401.7 ms) (p = 0.03). the mean heart rate was significantly different in cirrhotic patients (79.6 ± 2.9/bpm) compared to healthy controls (72.47 ± 2.0/bpm) (p = 0.05).conclusions: in this study, qt_c was prolonged and increased with the severity of cirrhosis, and its diurnal variation in cirrhosis was different from healthy subjects.