Abnormal Immunoglobulin Levels in Iranian Patients with Hematologic Malignancies

Introduction: hematologic malignancies can be associated with dysregulation of the immune system. there are some conflicting data regarding serum immunoglobulin levels in patients with such malignancies.material and method: in order to evaluate the humoral immunity of the patients with hematologic malignancies, 58 patients were enrolled in this study. 24 with acute lymphoblastic leukemia (all), 17 with acute myeloid leukemia (aml), eight with lymphoma, five with chronic lymphocytic leukemia, and four with multiple myeloma.results: there were six cases with decreased serum igg level (5 aml and 1 all). forty patients with elevated serum igg levels (69%).24 with elevated iga and/or igm level; 12 patients with elevation in all classes of immunoglobulin (8 all, 2 aml, and 2 lymphoma).conclusion: serum immunoglobulin levels can be abnormal in the patients with hematologic malignancies. abnormalities of igg, especially elevated level, seem to be the most frequent finding encountered in these patients.