Glyceryl Trinitrate Versus Magnesium Sulfate in the Suppression of Preterm Labor

Introduction: preterm births (before 37 completed week gestation) account for approximately 5-10% of births and are the major cause of perinatal mortality in north america and europe. this is largely because of a lack of standard treatments for this problem, therefore, the aim of this study was to compare glyceryl trinitrate with magnesium sulfate for their ability to suppress preterm labor.material and methods: a clinical trial was performed at the ali ebne abitaleb hospital, in the zahedan university of medical science. in total, 42 women with preterm labor and intact membranes with a gestational age between 27 and 37 weeks were divided into two groups at random. patients in the experimental group received glyceryl trinitrate (5mgr transdermal patches /24 hours) and in the control group, magnesium sulfate (at first 4 gr infusion: 1gr/min and then 2gr/hour) was used until the suppression of preterm uterine contractions was observed. results were obtained through observation and interview forms, and the resulting data was analyzed using chi square and t tests available in the spss statistical software (p <0.05). results: mean duration of pregnancy prolongation was 14.87 days in the case group (min: 11 max: 59.38 sd: 14.28) and 13.44 days in the control group (min: 26 max: 36.63 sd: 14.77). there was no significant difference in the prolongation of pregnancy between glyceryl trinitrate and magnesium sulfate (p<0.05).conclusion: glyceryl trinitrate is a suitable substitute for magnesium sulfate in the suppression of preterm labor