the association among vitamin d, insulin resistance, and obesity in turkish women

Background: vitamin d deficiency is common in patients with body mass index (bmi) higher than 25 kg/m^2. the aim of this study was to evaluate whether any correlation exists among 25 hydroxyvitamin d, bmi, and other biochemical parameters in turkish women subjects. methods: atotalnumberof 31 subjects with bmi ≥ 25kg/m^2 were included. these patients were, subsequently, divided into 2 groups according to their bmi. group 1 consisted of patients with bmi:25 - 34 kg/m^2 and group 2 with bmi 35 kg/m^2. venous blood samples were collected from the subjects in amorningfasting state to measureserumvit dlevels. high performance liquid chromatographymass spectrometry (hplc-ms) method was used for vit d measurement. the homeostatic model assessment (homa) was used to quantify insulin resistance (ir). results: a total number of 15 subjects (46.9%) had bmi 25 - 34 kg/m2 (group 1) and 17 subjects had bmi ≥ 35 kg/m^2 (group 2). vit d levels were 24.82± 13.7 ng/ml in group 1 and 23.56 ± 12.31 ng/ml in group 2. although vit d levels were lower than normal limits in both groups, they were not statistically different among the groups (p 0.901). although statistically insignificant, insulin levels were higher in group 2 than group 1 (19.68±7.91µu/ml vs 17.612.02µu/ml; p = 0.29) and insulin levels were negatively correlated with vit d (r = -0,631; p = 0,002; p < 0,05). homa-ir levels were insignificantly higher in group 2 patients than group 1 patients (5.10 2.89 vs 4.193.35; p = 0.25). homa-ir was negatively correlated with vit d (r = -0,456; p = 0.05). conclusions: we demonstrated decreased vit d levels and a negative correlation among serum insulin levels, homa-ir, and vit d in turkish obese women. epidemiological studies, also, indicate that vit d deficiency may be related with ir and the development of diabetes. further studies are needed.