|
|
|
|
assessment of recombination in the s-segment genome of crimean-congo hemorrhagic fever virus in iran
|
|
|
|
|
|
|
|
نویسنده
|
chinikar sadegh ,shah-hosseini nariman ,bouzari saeid ,shokrgozar mohammadali ,mostafavi ehsan ,jalali tahmineh ,khakifirouz sahar ,groschup h martin ,niedrig matthias
|
|
منبع
|
journal of arthropod-borne diseases - 2016 - دوره : 10 - شماره : 1 - صفحه:12 -23
|
|
چکیده
|
background: crimean-congo hemorrhagic fever virus (cchfv) belongs to genus nairovirus and family bunyaviridae. the main aim of this study was to investigate the extent of recombination in s-segment genome of cchfv in iran. methods: samples were isolated from iranian patients and those available in genbank, and analyzed by phylogenetic and bootscan methods. results: through comparison of the phylogenetic trees based on full length sequences and partial fragments in the s-segment genome of cchfv, genetic switch was evident, due to recombination event. moreover, evidence of multiple recombination events was detected in query isolates when bootscan analysis was used by simplot software. conclusion: switch of different genomic regions between different strains by recombination could contribute to cchfv diversification and evolution. the occurrence of recombination in cchfv has a critical impact on epidemiological investigations and vaccine design.
|
|
کلیدواژه
|
recombination ,phylogenetic ,diversity ,crimean congo hemorrhagic fever ,iran
|
|
آدرس
|
arboviruses and viral hemorrhagic fevers laboratory (national reference lab), pasteur institute ofiran, tehran, iran., Iran, Islamic Republic of, arboviruses and viral hemorrhagic fevers laboratory (national reference lab), pasteur institute ofiran, tehran, iran., Iran, Islamic Republic of, department of molecular biology, pasteur institute of iran, tehran, iran., Iran, Islamic Republic of, national cell bank of iran, pasteur institute of iran, tehran, iran., Iran, Islamic Republic of, department of epidemiology, pasteur institute of iran, tehran, iran., Iran, Islamic Republic of, arboviruses and viral hemorrhagic fevers laboratory (national reference lab), pasteur institute ofiran, tehran, iran., Iran, Islamic Republic of, arboviruses and viral hemorrhagic fevers laboratory (national reference lab), pasteur institute ofiran, tehran, iran., Iran, Islamic Republic of, friedrich-loeffler-institut, federal research institute for animal health, greifswald-insel riems,germany., Germany, robert koch institute, berlin, germany., Germany
|
|
پست الکترونیکی
|
sadeghchinikar@yahoo.com
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|