Simultaneous spectrophotometric determination of triamterene and hydrochlorothiazide in Triamterene-H tablets using continuous wavelet transformation

A spectrophotometric method for simultaneous analysis of triamterene and hydrochlorothiazide is proposedby application of continuous wavelet transform on the spectral data without time-consuming extraction step.different wavelets families were tested and coiflets wavelet family (coif1) and reverse birothogonal wavelets family(rbio 2.8) were selected and applied under the optimal conditions for simultaneous analysis.the validation of the developed methods was confirmed by analyzing various synthetic mixtures of the investigateddrugs.triamterene and hydrochlorothiazide could be determined simultaneously in the range of 0.75-5.0 ?g ml-1 and 1.0–6.0 ?g.ml-1 respectively and lod for triamterene and hydrochlorothiazide was less than 1.07 ?g.ml-1 and 0.89?g.ml-1 respectively.the experimental results obtained from the continuous wavelet transform approach were statistically compared withthose obtained by derivative spectrophotometry and successful results were reported.