Green Procedure For Synthesis of 3, 4 Dihydropyrimidinones Using 12-Molybdophosphoric Acid, As A Catalyst and Solvent Free Condition Under Microwave Irradiation

Simple and improved conditions have been found to carry out the biginelli reaction for the synthesis of3, 4-dihydropyrimidin-2(1h) - one derivatives. this synthesis was performed in the presence of 12-molybdophosphoricacid (h3pmo12o40) as catalyst. these reactions were performed under solvent free conditions with microwaveirradiation as the energy source. compared with the classical biginelli reaction conditions, this new method hasthe advantage of excellent yields (76–96%). the advantages of this novel protocol include the excellent yield,operational simplicity, short time, and the avoidance of the use of organic solvents and friendly preparation. products wereidentified using physical and spectroscopic data.