human papillomavirus infection and its association with lung cancer: a case-control study (2011–2019)

Background and objectives: human papillomavirus (hpv) causes about 4.5% of all new human cancers. the purpose of this study was to look into the prevalence of various hpv types in patients with lung cancer.materials and methods: the study included a cohort of 61 individuals who had received treatment at imam khomeini hospital in ahvaz between 2011 and 2019. paraffin-embedded tissues were used for molecular analysis. the primary goal was to assess the differences in hpv prevalence between lung cancer patients and a control group, using a nested pcr assay followed by sequencing.results: among the lung cancer patients, hpv dna was detected in 10 individuals, while three individuals in the control group were also positive (16.3% versus 12.0%, p=0.65). notably, every detected hpv variant was classified as the high-risk type 16. additionally, the researchers investigated potential associations between age, sex, smoking habits, and lung cancer in both hpv-positive and negative patients. the study findings revealed that age, sex, and smoking habits did not show statistically significant associations with the presence of hpv (p>0.05). moreover, lung cancer incidence was not significantly correlated with hpv infection (p>0.05).conclusion: therefore, according to the study's findings, smoking, hpv infection, and lung cancer prevalence were not significantly correlated in the population under investigation.