frequency of bk virus genotypes in patients with colorectal cancer

Background and objectives: bk polyomavirus infection is prevalent and primarily asymptomatic, except for complications in kidney transplant recipients. furthermore, its involvement in a tumorigenic family necessitates consideration in various malignancies such as urogenital tumors, prostate cancer, colorectal cancer (crc), and brain cancer. materials and methods: this investigation encompassed 50 specimens of colorectal adenocarcinoma tumors, 50 adjacent tissues, and 40 urine samples, with patients having a mean age of 61 years ± 12.4 years. the detection of bk virus dna vp1 gene and genotyping were carried out through nested-pcr and sequencing techniques.results: through the utilization of nested-pcr, bk virus dna was identified in 15/50 (30%) colorectal tumor samples and 3/50 (6%) adjacent tissues (p-value = 0.008). additionally, 6/40 (15%) urine samples exhibited positive results for bk virus dna. notably, among these findings, 9/15 bk virus positive tumor tissues (60%) and 3/6 bk virus positive urine samples (50%) were confirmed to be positive for bk virus subtype 4 (p-value < 0.001), whereas 2 tumor samples and 3 urine samples were attributed to bk virus type 1b2.conclusion: it is imperative to enhance one's understanding of the etiological and risk factors pertaining to cancers. the present findings offer substantiation of a potential correlation between bk virus infection and colorectal cancer. bk virus genotype 4 was found to be dominant among the crc patients in this study.