synthesis of new imidazole-based ionic liquids with antifungal activity against candida albicans

Background and objectives: candida albicans cause a problematic condition in immunocompromised patients that could not be treated quickly due to the resistant behavior of microorganisms. this study aimed to investigate the effect of a novel ionic liquid (il) as a new drug on c. albicans strains. materials and methods: seven newly binary ionic liquids mixtures were synthesized, and among them, ([prollinium chlo- ride] [1-methylimidazolium 3-sulfonate] ([pro-hcl][mims]) was selected and characterized by 1hnmr, 13c nmr, and ft-ir methods. samples from patients (n=50) with candidiasis were collected and identified through culture media. erg11 gene overexpression was related to resistance against azole-bearing drugs. the antibiogram, well diffusion assay, mics, and mfcs tests were operated. pcr and real-time evaluated the expression of the erg11 gene, and the rate of cell death was detected using flow cytometry. results: our data manifested that this novel il (ionic liquid) can inhibit c. albican's growth, reduce the expression of erg11 and increase dead cells. conclusion: the newly synthesized il had an inhibiting effect on the growth of the c. albicans strains and may be used as an alternative candidate for novel drug design.