in vitro antifungal potency of the moronecidin-like peptide against candida albicans, candida glabrata, and candida tropicalis

Background and objectives: the aim of this study was to investigate the in vitro antifungal potency of the moronecidin-likepeptide against candida albicans, candida glabrata, and candida tropicalis.materials and methods: to evaluate the antifungal effect of moronecidin-like peptide, the protocol presented in clsi m27-a3 and clsi m27-s4 was used and the minimum inhibitory concentration was determined.results: the minimum inhibitory effect of moronecidin-like peptide composition was 8 μg/ml for candida tropicalis and candida albicans and 32 μg/ml for candida glabrata. the mic of nystatin was determined to be 1.25 μg/ml for candida glabrata and candida albicans and 0.625 μg/ml for candida tropicalis strains. the mfc composition of the moroneci- din-like peptide was determined for candida tropicalis and candida albicans strains 8 μg/ml and for candida glabrata strain64 μg/ml. the results of cytotoxicity and hemolysis of the moronecidin peptide test on macrophage showed that moronecidinpeptide has no cytotoxicity and toxicity properties.conclusion: according to the results of the present study, the moronecidin-like peptide could be a new strategy in the treat- ment of infections caused by candida strains. the discovery of the exact mechanism of which requires extensive clinical studies in this field.