inhibition of bacterial adhesion and anti-biofilm effects of bacillus cereus and serratia nematodiphila biosurfactants against staphylococcus aureus and pseudomonas aeruginosa

Background and objectives: biosurfactants are amphiphilic surface-active agents that mainly produced by various microorganisms. in this study, the anti-biofilm and inhibition of bacterial adhesion activities of two bacterial biosurfactants were investigated.materials and methods: after extraction and evaluation of bacillus cereus and serratia nematodiphila biosurfctants, inhibition of bacterial adhesion and anti-biofilm effects of them on staphylococcus aureus and pseudomonas aeruginosa were determined.results: on average, the synergistic effect of two bacterial biosurfactants, caused about 60% decrease in adhesion and about 80% decrease in biofilm formation of s. aureus and p. aeruginosa.conclusion: the results of this study showed that combination of b. cereus and s. nematodiphila biosurfactants would increase the potential of attachment inhibition and biofilm eradication with very low toxicity.