distribution of human papillomavirus genotypes in suspected women cytological specimens from tehran, iran

Background and objectives: the human papillomavirus (hpv) is associated with more than 70% of the cervical neoplasm. the current study aims to evaluate the distribution of hpv genotypes in suspected women cytological specimens from teh- ran, iran.materials and methods: in the current cross-sectional study, hpv genotype prevalence was investigated in 433 subject women. dna extraction was performed by high pure viral nucleic acid kit. a semi-automatically hybrispot 24™ (hs24) setting was used for hpv typing and data interpreted by hybrisoft™ software according to instructions.results: pathologic data showed 181 (41.8%) had non-malignant lesions, 212 (49%) had inflammation and 40 (9.2%) reported lsil in primary pap-smear result. hpv was found in 143 (33%) specimens and the most comment high-risk and low-risk hpv types were hpv-16 and -6, respectively. also, 62 (43%) were co-infected with multiple genotypes includes,34 (24%) cases had co-infection with two hpv types, 17 (12%) cases had co-infection with three hpv types, 6 (4%) cases had co-infection with four hpv types and 5 (3%) cases had co-infection with five hpv types. there was statistically different domination on high-risk genotype in most of the co-infected samples (p<0.01).conclusion: current study indicates that the lesion pathology assessment was significantly associated with the hpv infec- tion (p<0.01). furthermore, the age group assessment shows that most of the hpv positive cases were 21 to 40 (p<0.01). the hpv infection prevalence in the current study was 33% and the most frequently reported high-risk and low-risk hpv types were 16 and 6, respectively.