retracted article: the effect of a singlestrain probiotic administration in the treatment of thermal burns patients

Background and objectives: between 2007 and 2011, the mortality rate for burns patients at dr. soetomo general hospital, surabaya, indonesia was 14.1% and 60% were suspected to be sepsisrelated. immunosuppression, gut barrier disruption, and intestinal hypomotility cause bacterial and bacterial product translocation. probiotics improve the intestinal microbiome and eventually reduce bacterial translocation, and an increased secretory immunoglobulin a (siga) secretion postadministration of a multispecies probiotic has been observed. we aimed to determine whether a singlestrain probiotic administration could show strengthened intestinal immunity, through an increase in siga levels, as with multistrain probiotics. materials and methods: sixteen burns patients from our hospital burns centre were randomized into three treatment groups, and the patients were administered either a placebo, a lactobacillus reuteri protectis probiotic, or a bifidobacterium infantis 35624 probiotic for 14 consecutive days. the siga levels were analyzed using elisa pre and posttreatment. results: the posttreatment sigalevelsin the placebo, lactobacillusreuteri protectis probiotic, and bifidobacterium infantis 35624 probiotic groups were 222.56±74.22 mg/dl, 223.92±68.89 mg/dl, and 332.38±64.27 mg/dl, respectively. decreased siga levels were observed in the placebo (7.19±15.87) and in the lactobacillus reuteri protectis probiotic (1.9920±14.76) groups, whereas an increase was seen in the siga level in the bifidobacterium infantis 35624 probiotic group (58.26±77.41). conclusion: the bifidobacterium infantis 35624 singlestrain probiotic is generally superior to lactobacillus reuteri protectis in altering intestinal immunity; however, this finding was not statistically significant. a multistrain probiotic supplement is recommended for burns patients.