antifungal susceptibility of non-albicans candida spp. isolated from raw milk and human blood in alborz and tehran provinces

Background and objectives: recent reports indicate high prevalence of fungal infections due to nonalbicans candida spp. which are present in various environments such as raw milk. the quality of milk for fungal normal flora was investigated in this study. materials and methods: a total of 262 milk samples were collected directly from milk collection tanks indesignated dairy farms and cultured in sda media. by further analysis of grown yeasts, 69 nonalbicans candida strains were identified. antifungal susceptibility of the isolated species, were evaluated against amphotericin b, itraconazole, fluconazole and flucytosine. fifty two nonalbicans clinical samples isolated from human blood have been evaluated along. results: antifungal susceptibility evaluation in nonalbicans strains isolated from milk revealed candida glabrata and candida tropicalis to be 100% sensitive to flucytosine and fluconazole. candida krusei showed 94% and 80% sensitivity to flucytosine and fluconazole respectively. candida parapsilosis indicated 72.72% sensitivity to fluconazole.conclusion: evaluation of nonalbicans candida species in raw milk and antifungal susceptibility patterns of these isolatescompare with non-albicansisolates from human blood, may help physicians to choose an appropriate medication for diseases needing longterm treatment, especially for diseases caused by local strains.