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   Evaluation of a Binary Carrier System for the Dissolution Enhancement of a High Dose Poorly Soluble Drug  
   
نویسنده Al-Muhaissen Suha A. ,AlKhalidi Bashar ,Bustanji Yasser ,Aiedeh Khaled ,Mohammad Mohammad K. ,AlKhatib Hatim S
منبع jordan journal of pharmaceutical sciences - 2012 - دوره : 5 - شماره : 1 - صفحه:30 -40
چکیده    The role of two surface active carriers, gelucire® 44/14 and lutrol® f127, for improvement of solubility and dissolution of the high-dose, poorly water-soluble drug, albendazole, using solid dispersion approach was evaluated. the solubility of albendazole in solutions of the studied carriers and binary mixtures showed improvement, with solutions containing higher percentages of lutrol® f127 as best solvents. albendazole was then incorporated in matrices made of either carrier alone or mixtures of the two carriers at different ratios using a melting procedure. the resulting particles were compressed into tablets. in vitro dissolution of particles and tablets showed fast dissolution. increased wettability of albendazole by the carriers and formation of partial solid solutions of it in the carrier system were shown to be the mechanisms of the improvement in its dissolution
کلیدواژه Albendazole ,Gelucire® ,Lutrol® ,solid dispersions ,dissolution enhancement ,pharmaceutical tablets
آدرس University of Jordan, Faculty of Pharmacy, Jordan, University of Jordan, Faculty of Pharmacy, Jordan, University of Jordan, Faculty of Pharmacy, Jordan, University of Jordan, Faculty of Pharmacy, Jordan, University of Jordan, Faculty of Pharmacy, Jordan, University of Jordan, Faculty of Pharmacy, Jordan
 
     
   
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