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Simultaneous Determination of Some Pharmaceuticals in Hospital Effluents Using HPLC with UV and Fluorescence Detectors
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نویسنده
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Alawi Mahmoud A. ,Alahmad Waed
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منبع
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jordan journal of pharmaceutical sciences - 2012 - دوره : 5 - شماره : 1 - صفحه:21 -29
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چکیده
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The development and validation of an hplc/uv/fluorescence (fl) detection method is described, whichenables the measurement of the most consumed pharmaceuticals (methotrexate, caffeine, diclofenac, glimepirideand ibuprofen) in jordanian hospital effluents. separation was done on a rp-c8 column at a flow rate of 1ml/min using 1:1 h2o/acetonitrile with 0.1% trifluoroacetic acid. the samples (200 ml each) were extracted andcleaned-up on c18 cartridges. correlation coefficients of the pharmaceuticals calibration were higher than 0.997using a uv detector and 0.996 using a fluorescence detector for methotrexate. recoveries were ranged from87% to 108.3%
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کلیدواژه
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Pharmaceutical; Methotrexate ,Diclofenac ,Glimepiride ,Ibuprofen ,HPLC/UV ,Fluorescence ,aqueous samples ,hospital wastewater
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آدرس
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University of Jordan, Department of Chemistry, Jordan, University of Jordan, Department of Chemistry, Jordan
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Authors
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