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Mega-dose Vitamin C: Is it Harmful to the Liver? Biochemical and Histological Study in Rats
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نویسنده
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Abdul-Razzak Khalid ,Yacoub Mohammed ,Hananeh Wael ,Arif Shayma’a
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منبع
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jordan journal of pharmaceutical sciences - 2012 - دوره : 5 - شماره : 1 - صفحه:8 -20
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چکیده
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Aim: to investigate if mega-doses of vitamin c would have deleterious effects on the liver in an animal model.methods: a mega-dose of vitamin c (1000 mg/kg/day) was administered by oral gavage to male wistar rats for60 days. both biochemical and histopathological measures were undertaken.results: the results showed that a mega-dose of vitamin c significantly elevated lipid peroxidation andtransaminase activity level in addition to the significant suppression of antioxidant enzymes activities. theseresults were consistent with the presence of histological lesions.conclusion: a mega-dose of vitamin c is not safe and can cause liver injury
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کلیدواژه
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Mega-dose ,vitamin C ,liver lesions
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آدرس
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Jordan University of Science and Technology, Faculty of Pharmacy, Jordan, Jordan University of Science and Technology, Faculty of Medicine, Jordan, Jordan University of Science and Technology, Faculty of Veterinary Medicine, Jordan, Jordan University of Science and Technology, Faculty of Medicine, Jordan
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Authors
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