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Simultaneous Spectrophotometric Determination of Tramadol and Acetaminophen in Pharmaceutical FormulationsUsing H-Point Standard AdditionMethod
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نویسنده
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Zarei Ali Reza ,Mardi Kobra ,Chalavi Soheila
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منبع
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jordan journal of pharmaceutical sciences - 2013 - دوره : 6 - شماره : 1 - صفحه:48 -55
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چکیده
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H-point standard addition method (hpsam) was applied to the simultaneous spectrophotometric determination of tramadol and acetaminophen in pharmaceutical formulations. the results showed that tramadol and acetaminophen can be determined simultaneously in the range 5.0-100 and 1.0-10 μg/ml, respectively. the limits of detection (lod) for tramadol and acetaminophen were obtained 2.0 and 0.50 μg/ml, respectively. relative standard deviation for five replicate simultaneous determinations of tramadol and acetaminophen were calculated to be 3.2 and 3.3%, respectively. the proposed method has been successfully applied to the simultaneous determination of tramadol and acetaminophen in some synthetic, pharmaceutical formulation.
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کلیدواژه
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Tramadol ,Acetaminophen ,Spectrophotometric ,H-point standard addition method ,Pharmaceuticalformulation
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آدرس
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malekeashtar university of technology, Faculty of Chemistry and Chemical Engineering, ایران, malekeashtar university of technology, Faculty of Chemistry and Chemical Engineering, ایران, malekeashtar university of technology, Faculty of Chemistry and Chemical Engineering, ایران
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Authors
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