A review of antifungal peptides: Basis to new era of antifungal drugs

The limited arsenal of antifungal drugs coupled with the growing number of drug resistant isolates of yeast pathogens stresses the need for the development of new antifungal agents with new mechanisms of action. antimicrobial peptides,an active arm of the innate immunity,represent the natural arsenal against pathogens including the yeast. this review is focused on studying the biophysical prosperities of antifungal peptides enclosed within the antimicrobial peptides database. studying these peptides may be the key for discovering and developing of new potent antifungal agents as they have served as model in drug discovery . furthermore,the review discusses the main obstacles and barriers that prevent antifungal peptides from becoming successful drug stories specifically the salt in tolerance . proposed solutions from industry and nature are also discussed. this review serves as a potential base for utilizing antifugal peptides in drug discovery. © 2016 dar publishers/the university of jordan. all rights reserved.