Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population

Introduction: human leukocyte antigen (hla) genes are the most polymorphic loci in the human genome. they predict the outcome of transplantation by detecting self from non-self antigens. the best use of hla typing is to find a hla-match donor for bmt candidate patients. evidence suggests that matching unrelated donors and recipients for hla-a, -b and -drb1 loci is a prediction for an improved outcome.methods and materials: hla-a and -b of six hundred iranian cord blood samples were typed by pcr-ssp method and the frequency of loci were estimated. results: the most frequent alleles were a*02(18.16), a*24(16.41), b*35(21.66) and b*51(13.35),respectively. discussion: our hla typing data show similarity between neighbor and related countries and caucasians. identifying hla alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation.