Predictive Factors of Survival Time after Hematopoietic Stem Cell Transplant in Acute Myeloid Leukemia Patients who Received Allogeneic BMT from Matched Sibling Donors Using Generalized Gamma Models

Introduction: this paper used generalized gamma (gg) distribution to find the predictive factors of overall survival (os) after haematopoietic stem cell transplant (hsct) in acute myeloid leukemia patients.methods: discrimination among the exponential, weibull, gg, log-logistic, and lognormal distributions was done using maximum likelihood and akaike information criteria. results: the 5-year os in 301 patients was 65% (95%ci: 60.7-69.3). peak mortality hazard occurred at months6-7 after hsct then, it was u shape. the data was fitted by gg distribution better than other distributions. univariate analysis using gg distribution showed a positive association between os with dose of infused wbc (p=0.018), cd3 (p=0.001), no relapse (p<0.001), cgvhd (p<0.001), and platelet recovery (p<0.001). multivariate analysis indicated that, os has relationship with relapse (p<0.001), platelet recovery (p=0.004), disease status at transplant (p=0.036) and agvhd (p=0.036). conclusion: we showed that gg distribution can be a useful tool for recognizing prognostic factors of os in aml patients.