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clinical use of statins in hematopoietic stem cell transplantation: old drugs and new horizons
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نویسنده
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mohammadi mehdi ,vaezi mohammad ,mirrahimi bahador ,hadjibabaie molouk
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منبع
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international journal of hematology-oncology and stem cell research - 2016 - دوره : 10 - شماره : 1 - صفحه:42 -50
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چکیده
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hydroxymethylglutaryl co-enzyme a reductase inhibitors, also known as statins, are a class of anti-hyperlipidemic agents. these drugs have been employed vastly to reduce the morbidity and mortality of cardiovascular disorders. soon after their introduction, benefits other than their primary actions were discovered. along with these pleiotropic properties, a series of mainly favorable effects has been proposed in patients intended to undergo hematopoietic stem cell transplantation. these actions address some complications encountered by this special population such as graft-versus-host disease, efficacy of chemotherapy, infections, etc. this review presents the current evidence surrounding these issues.
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کلیدواژه
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infection ,gvhd ,statin ,stem cell transplantation
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آدرس
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clinical pharmacy department, faculty of pharmacy, tehran university of medical sciences, tehran, iran, Iran, Islamic Republic of, hematology-oncology and stem cell research center, tehran university of medical sciences, tehran, iran, Iran, Islamic Republic of, clinical pharmacy department, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran, Iran, Islamic Republic of, research center for rational use of drugs, tehran university of medical sciences, tehran, iran, Iran, Islamic Republic of
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پست الکترونیکی
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hajibaba@tums.ac.ir
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Authors
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