Association between Interlukin-6 (IL-6),Interlukin-10 (IL-10) and depression in patients undergoing hematopoietic stem cell transplantation

Background: the release of pro-inflammatory cytokines is responsible for the variety of behavioral,neuro-endocrine and neuro-chemical alterations in psychiatric condition. in this study we evaluate relation between depression and il-6 and il-10 in patients undergoing hematopoietic stem cell transplantation (hsct). materials and methods: 66 patients in this cross-sectional study from july 2013 until august 2014 for hsct interred the study and were assessed for depression using hospital anxiety and depression scale (hads). serum interleukin (il)-6,(il)-10 and high sensitive c-reactive protein (hs-crp) were assessed on the same time. association between these biomarkers with depression was evaluated using spss version 20. results: a total of 66 patients with the mean age of 41.18+13.92 and 41.95+12.35 years old in non depressed and depressed group respectively were enrolled in this study. patients with depression showed significantly higher levels of serum il-6 and the il-6-to-il-10 ratio compared to patients without depression (p<0.001).there was no statistically significant association between il-10 and hs-crp with depression in this group of the patients. conclusions: high il-6 level has significant association with depression in patients undergoing hsct. in conclusion,since il-6 can affect the outcomes after hsct and depression was associated with increased serum il-6 level,early identification of depression can be beneficial in these patients. © 2015,tehran university of medical sciences (tums). all rights reserved.