The comparison of plasma D-dimer levels in benign and malignant tumors of cervix,ovary and uterus

Background: thromboembolism is the most important complication of cancers. the aim of this study was to determine d-dimer levels in benign and malignant tumors of the uterus,ovary and cervix. subjects and methods: this was a cross sectional study and it was conducted on 90 female patients referred to imam khomeini and arash hospitals because of uterine,cervical and ovarian tumors in 2013-2014. after surgical resection or tissue biopsy,2 cc of each patient’s blood was taken to be sent to laboratory of hospitals. “nycocard” kit was chosen to measure d-dimer levels in mg/lit by neflumetry method. data were analyzed in spss-16 by t-test and one-way anova test. results: the highest mean of d-dimer was 3.9 (± 2.9sd) in malignant cervical tumors. the mean plasma levels of d-dimer in malignant uterine cancers (p = 0.008),ovarian cancers (p = 0.007) and cervical cancers (p = 0.006) was significantly higher than benign tumors. in all three types of uterine,ovarian and cervical cancers,d-dimer was significantly higher in advanced stages than lower stages. conclusion: the plasma d-dimer levels in patients with malignant tumors of the uterus,cervix and ovary were higher than benign types. by increasing the stage of gynecologic malignant tumors,the levels of plasma d-dimer were increased. © 2015,tehran university of medical sciences (tums). all rights reserved.