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Lymphoid Genes Expression in Mouse Embryonic Stem Cells with Differentiation on Feeder Free Condition
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نویسنده
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Mossahebimohammadi Majid ,Kaviani Saeid ,Soufizomorrod Mina ,Soleimani Masoud ,Abroun Saeid ,Khamisipour Gholamreza ,Saki Najmaldin
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منبع
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international journal of hematology-oncology and stem cell research - 2012 - دوره : 6 - شماره : 2 - صفحه:22 -26
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چکیده
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Embryonic stem cells (escs) as pluripotent stem cells have the potential to give rise to all three germ layer cells. also, these cells have the self-renewing ability. escs could differentiate into most of cell lineages. lymphocytes generated from hematopoietic stem cells. we designed a feeder free culture condition to generate lymphoid lineage cells from escs. we demonstrated that il-7 plays critical role in differentiation of escs into lymphoid lineage and expression of specific cell markers such as cd3, cd19 and cd25 after 14 days of differentiation by rt-pcr.
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کلیدواژه
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Genes Expression ,Mouse Embryonic Stem Cells ,Differentiation ,Feeder Free Condition
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آدرس
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tarbiat modares university, Department of Hematology and Blood banking, ایران, tarbiat modares university, Faculty of Medical Sciences, Department of Hematology and Blood banking, ایران, tarbiat modares university, Department of Hematology and Blood banking, ایران, tarbiat modares university, Department of Hematology and Blood banking, ایران, tarbiat modares university, Department of Hematology and Blood banking, ایران, bushehr university of medical sciences, Department of Allied Medicine, ایران, ahvaz jundishapur university of medical sciences, Research Center of Thalassemia & Hemoglobinopathy, ایران
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Authors
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