Immunohistochemical Analysis of p53, Ki-67, CD44, HER-2/neu Expression Patterns in Gastric Cancer, and Their Association with One Year Survival in North-West of Iran

Introduction: gastric cancer remains the second most common cause of cancer-related deaths worldwide. in many malignancies like, lung and breast, multiple prognostic factors are known, such as mutations in ki-67, her-2/neu, p53. in this study, we evaluated immunohistochemical protein expression patterns of cell-cycle-regulators p53, proliferation marker ki-67, surface expression of cd44, her-2/neu oncogene proposed as useful prognostic factors. methods: in this descriptive-analytic study, we evaluate 100 patients with gastric cancer who were referred to shahid ghazi hospital or other oncology clinics of tabriz university of medical sciences in 2005-2010. patients with pathologic confirmation of gastric cancer were selected. expression of p53, ki-67, cd-44, her-2/neu were detected by immunohistochemical staining. results: in this study, 100 patients with gastric cancer participated. 76(76%) were men and 24(24%) were women with mean age of 64.02 (8.05) years. seventy two samples were intestinal type and 28 were diffuse type. cd44 was positive in 27(27%) patients. p53 was positive in 35(35%) patients. ki-67 was positive in 53(53%) patients. her-2/neu was positive in 51(51%) patients. conclusion: the frequency of positive p53, ki-67, cd44 and her-2/neu varied in different studies. positive ki-67 and her-2/neu were not associated with changes in survival but positive p53 and cd44 were significantly associated with improved survival.