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Anti-CD20 Antibody is Effective in the Patient with Refractory Amegakaryocytic Thrombocytopenia, 25 Months Follow up
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نویسنده
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Mirzania Mehrzad ,Khalili Sedigheh ,Hasanpoor Akbar ,Shamshiri Ahmad Reza
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منبع
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international journal of hematology-oncology and stem cell research - 2014 - دوره : 8 - شماره : 2 - صفحه:41 -44
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چکیده
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Amegakaryocytic thrombocytopenia (amt) is a rare cause of acquired thrombocytopenia. the pathogenesis and treatment of amt is not clearly known. here we demonstrate a 50-year-old man presented with the clinical manifestations of severe thrombocytopenia (7000 platelets/μl) with a marked decrease to absent of megakaryocytes in the bone marrow. the patient did not respond to intravenous immunoglobulin, cyclosporine or high dose prednisone. after the treatment with anti-cd20 antibody (rituximab), the patient’s clinical symptoms and platelet counts improved.
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کلیدواژه
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Amegakaryocytic thrombocytopenia; Anti-CD20 antibody; Platelet
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آدرس
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tehran university of medical sciences tums, Imam Khomini Hospital Complex, Vali-e-Asr Hospital, ایران, arak university of medical sciences, ایران, arak university of medical sciences, ایران, tehran university of medical sciences tums, Hematology- Oncology and Stem Cell Research Center, ایران
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Authors
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