high-burden metastatic prostate cancer mimicking lymphoma: a case of extensive lymphadenopathy

Supradiaphragmatic lymphadenopathy is a rare finding in prostate cancer. the occurrence of multiple lymphadenopathies forming a conglomerate that resembles lymphoma is also rarely encountered in prostate cancer diagnosis. we present the case of a 71-year-old man who has experienced bilateral leg swelling in the last four months. multiple lymphadenopathies were detected in the intra-abdominal and supradiaphragmatic regions, along with several metastatic bone lesions. histopathological and immunohistochemical evaluations confirmed a diagnosis of prostate adenocarcinoma, not otherwise specified (nos), with a gleason score of 4+3=7, classified as grade group iii, indicating high-volume metastatic prostate cancer. the patient was treated with docetaxel and anti-androgen therapy. his condition was improved after eight cycles of chemotherapy, and his prostate-specific antigen (psa) levels returned to normal.