sweet's syndrome as a prodromal manifestation of acute myeloid leukemia

Sweet's syndrome is a rare dermatological condition characterized by a constellation of clinical features, including fever, neutrophilic leukocytosis, painful skin plaques, and dermal neutrophil infiltration. various etiologies have been documented, encompassing both underlying diseases and pharmacological agents. we present a case involving a 35-year-old female patient who exhibited fever and progressive cutaneous lesions manifesting as a painful erythematous rash on the limbs and trunk. initially misdiagnosed as seronegative lupus erythematosus, her condition did not improve. a skin biopsy revealed significant neutrophilic infiltration, and she subsequently developed leukocytosis, leading to a diagnosis of acute leukemia upon bone marrow examination. the patient was treated with chemotherapy, resulting in a relative improvement of her skin lesions.