the relationship between the lifestyle of the allogeneic stem cell donors and the number of donated cd34+ and cd3+ cells

Background: hematopoietic stem cell transplantation (hsct) is considered as the last treatment option for many life-threatening diseases. the number of donated cells can affect transplantation success. this study attempted to investigate the relationship between the health-promoting lifestyle of allogeneic stem cell donors and the number of donated cd34+ and cd3+ cells.materials and methods: the study was a descriptive correlational study in which 100 peripheral blood stem cell donors participated. a demographic form and health-promoting lifestyle profile-ii questionnaire were distributed to participants, and then cell separation was started. afterward, the results of cd34 + and cd3 + cell counts, as well as other clinical parameters of the participants, were recorded. the collected data were analyzed by descriptive and analytical statistical methods.results:  the results showed that the mean total health-promoting lifestyle profile score for hematopoietic stem cell donors was 2.876±0.461. there was no significant relationship between the health-promoting lifestyle score and the number of cd34+, cd3+ cells and cd3+/cd34+ ratio. a positive and significant correlation was found between the weight of the donors and the number of cd34+ (p < 0.001) and cd3+ cells (p = 0.001). the number of cd34+ cells was significantly different between women and men (p = 0.009).conclusion: lifestyle had no significant effect on the number of cd3+/cd34+ cells. moreover, the number of cd34+ cells was significantly higher in men, so males should be preferentially recruited as donors for the hsct procedure.