combined haploidentical hematopoetic stem cell transplantation and liver transplantation in a pediatric patient

Solid organ transplantation from the same donor is an established procedure for end-stage organ failure that developed after a previous hematopoietic stem cell transplantation (hsct); however, it is rarely done in patients transplanted with unmanipulated haplo-hsct. there are no pediatric reports regarding the long-term performance of organ transplantation after haplo-hsct with post-transplant cyclophosphamide (ptcy).a juvenile myelomonocytic leukemia patient, who underwent unmanipulated haplo-hsct with ptcy from her mother at the age of 3 years, developed chronic liver graft versus host disease (gvhd) which was refractory to specific gvhd treatment. liver transplantation (lt) from her mother (the donor of her haplo-hsct) was decided as the next line of treatment.lt was performed on day 540 post-hsct, and the donor's left lateral segment was appropriately removed and attached to the recipient. the symptoms of gvhd completely regressed in a month. the patient died on day 121 after lt, because of a possible hepato-pulmonary syndrome.organ failure can develop after allo-hsct secondary to gvhd and therefore performing hsct from a haplo-donor may be superior to a matched unrelated donor in terms of subsequent organ transplantation for organ failure.