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Systemic and Craniospinal Rosai Dorfman Diseasewith Intraparenchymal, Intramedullary andLeptomeningeal Disease
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نویسنده
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li yi ,sloan emily ,bollen andrew ,solomon david ,theodosopoulos philip ,cha soonmee
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منبع
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international journal of hematology-oncology and stem cell research - 2021 - دوره : 15 - شماره : 4 - صفحه:260 -262
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چکیده
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Rosai dorfman disease is a rare histiocytic disorder of over-production of non-langerhans histiocytes, which typically manifests with massive lymphadenopathy and sinonasal involvement. we report a rare case of systemic and disseminated craniospinal rosai-dorfman disease with intraparenchymal and leptomeningeal involvement, but no sinus or dural-based disease. the diagnosis was established by biopsy of a hypothalamic mass. additionally, ucsf500 next generation sequencing demonstrated a solitary pathogenic alteration affecting the braf oncogene, which supports the morphologic and immunohistochemical diagnosis of rosai-dorfman disease.
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کلیدواژه
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Rosai dorfman disease; histiocytosis; BRAF
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آدرس
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university of california san francisco, department of radiology and biomedical imaging, USA, university of california san francisco, department of pathology, USA, university of california san francisco, department of pathology, USA, university of california san francisco,, department of pathology, USA, university of california, department of neurological surgery, USA, university of california san francisco, department of radiology and biomedical imaging, USA
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Authors
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