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Hemoglobinopathies in Iran: An Updated Review
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نویسنده
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nasiri abolfazl ,rahimi zohreh ,vaisi-raygani asad
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منبع
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international journal of hematology-oncology and stem cell research - 2020 - دوره : 14 - شماره : 2 - صفحه:140 -150
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چکیده
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Hemoglobinopathies are the most common single gene disorders (monogenic disorders) in the world population. due to specific position of iran and the presence of multi-ethnic groups in the country, there are many varieties in the molecular genetics and clinical features of hemoglobinopathies in iran. hemoglobinopathies include structural variants, thalassemias, and hereditary persistence of fetal hemoglobin. in this review, we look at the common structural variants in various parts of the country along with their hematological and clinical characteristics. also, we discuss about the burden of the thalassemias in the country, different types, complications, molecular defects and therapy.
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کلیدواژه
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Hemoglobinopathies; Thalassemia ,Hb S ,Hb D ,Mutation
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آدرس
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kermanshah university of medical sciences, students research committee, department of clinical biochemistry, Iran, kermanshah university of medical sciences, medical biology research center, health technology institute, department of clinical biochemistry, Iran, kermanshah university of medical sciences, fertility and infertility research center, health technology institute, department of clinical biochemistry, Iran
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Authors
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