Primary Vaginal Chloroma: A Rare Case Report

Chloroma (granulocytic sarcoma or myeloid sarcoma) is a rare malignant extra-medullary neoplasm of myeloid precursor cells. it is usually associated with myeloproliferative disorders but very rarely may precede the onset of leukaemia. here we are presenting a rare case of chloroma in a female patient without initial presentation of aml. 38 year old female patient, with performance score-1 had complaining of per vaginal bleeding for 1-2 days. patient consulted gynaecologist and underwent biopsy from anterior fornix of vagina. biopsy material was positive for lca (leukocyte common antigen), mpo (myeloperoxidase), c-kit positive on ihc (immunohistocytochemistry) while negative for cytokeratin, synaptophysin, chromogranin, cd20 (cluster of differentiation. whole body ct scan was non informative except mass lesion at vagina. patient was given 3+7 induction chemotherapy which was tolerated well followed by high dose cytarabine as consolidation therapy.