|
|
|
|
Molecular Mechanisms of Hemoglobin F Induction
|
|
|
|
|
|
|
|
نویسنده
|
Farshdousti Hagh Majid ,Dehghani Fard Ali ,Saki Najmaldin ,Shahjahani Mohammad ,Kaviani Saied
|
|
منبع
|
international journal of hematology-oncology and stem cell research - 2011 - دوره : 5 - شماره : 4 - صفحه:5 -9
|
|
چکیده
|
Hemoglobin f (hbf, α2γ2) is a major contributor to the clinical heterogeneity and ameliorating agent observed in patients with the ß-globin disorders including ß-thalassemia and sickle cell disease (scd). during fetal life, hbf is the major hemoglobin but is largely substituted by adult hemoglobin (hba, α2ß2) following a globin expression switch after birth. increased γ-globin expression can reduce the clinical severity of ß-thalassemia and scd. therefore, increase in hbf production has served as a longstanding goal. the progression of target-based therapeutics has been confused by limited comprehension of molecular mechanisms of gamma-globin gene expression. however, recent discoveries of regulators of hbf level represent a major development and provide new opportunities in employing novel rational therapeutic strategies. in this review, molecular mechanisms of hemoglobin f induction will be discussed
|
|
کلیدواژه
|
Hemoglobin F ، β-thalassemia ، Expression ، Induction
|
|
آدرس
|
tabriz university of medical sciences, Hematology and Oncology Research Center, ایران, tarbiat modares university, Faculty of Medical Sciences, Department of Hematology and Blood Banking, ایران, ahvaz jundishapur university of medical sciences, Research Center of Thalassemia and Hemoglobinopathies, ایران, tarbiat modares university, Faculty of Medical Sciences, Department of Hematology and Blood Banking, ایران, tarbiat modares university, Faculty of Medical Sciences, Department of Hematology and Blood Banking, ایران
|
|
پست الکترونیکی
|
kavianis@modares.ac.ir
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|