Expression analysis of long non-coding PCAT-1 in breast cancer

Background: the prostate cancer-associated non-coding rna transcript 1 (pcat-1) is a newly identified long non- coding rna whose participation in tumorigenesis of a variety of cancers has been observed. in the present study,we aimed at analysis of its expression in breast cancer patients. subjects and methods: the expression of pcat-1 was assessed using real-time reverse transcription polymerase chain reaction in tumor samples obtained from 47newly diagnosed breast cancer patients as well as their corresponding adjacent non-cancerous tissues (ancts). results: we detected significant over-expression of pcat-1 in 12/47 (25.5%) of tumoral tissues compared with their corresponding ancts. however,no significant association has been found between the levels of pcat-1 transcripts and patients’ clinical data such as tumor size,stage,grade,estrogen and progesterone receptors or her2/neu status. conclusion: pcat-1 is possibly involved in the pathogenesis of fraction of breast cancers. future studies are needed to evaluate its precise function in breast cancer. © 2017 tehran university of medical sciences (tums). all rights reserved.