Prevalence of G6pd Deficiency in Children With Hepatitis A

Introduction: hepatitis a virus is the most prevalent viral hepatitis. it is globally a major public health problem with different clinical symptoms. this study aimed at investigating the clinical findings and prevalence of glucose 6-phosphate dehydrogenase (g6pd) deficiency in children with hepatitis a. materials and methods: in this prospective study,demographical information,clinical findings,and g6pd level of hepatitis a patients,who were visited at pediatric hematology clinic,were entered into the database. the diagnosis of hepatitis a infection was based on the presence of anti-hav igm antibody. the activity of g6pd enzyme was measured with florescent spot test. results: of the 117 children with hepatitis a,52 (44.4%) were male and 65 (55.6%) were female. the mean age of these patients was 2.79±5.39 years. the most prevalent clinical manifestations were dark yellow urine and anorexia. g6pd deficiency was observed in 26 (26.3%) out of 99 patients whose g6pd levels were measured. conclusion: given the high prevalence of g6pd deficiency in this study,the measurement of g6pd level along with other liver and biochemical markers in areas with endemic hepatitis a is recommended. in addition,it is recommended that patients undertake precise monitoring for hemolysis and renal function. © 2017,tehran university of medical sciences (tums). all rights reserved.