Urinary Calcium/Creatinin Ratio with Different Dosages of Vitamin D3 Prophylaxis in Infants.

Objective: the requirement of vitamin d for breast-fed term infants remains an area of controversy. different dosage is needed according to environmental factors such as sunlight exposure. reception of more than 400 i.u. of vitamin d daily produces hypercalcemia. a random urine calcium/creatinin ratio (uca/cr) is a screening test for detection of hypercalciuria. setting adequate values of vitamin d3 prophylaxis by random uca/cr in infant population of yazd city in iran, is the aim of present study.methods: a total of 90 healthy, full term newborns of both genders were enrolled in the study. they were divided equally into three receiving vitamin d3 prophylaxis groups as follow: (i) 200 iu/daily, (ii) 400 iu/daily and (iii) 50000 iu two times in fifteen and sixty days after birth. a random urine specimen from each subject was analyzed for calcium, creatinin and serum 25-hydroxy-vitamin d at the end of three months of life.findings: from all 90 studied infants, 25 (83.3%) infants with 200 iu/daily vitamin d3, 23 (76.7%) infants with 400 iu/daily vitamin d3 and 28 (93.3%) who received 50000 iu two times (76 infants, 84.4%) had hypercalciuria and 14 (15.6%) infants remained with low values of ca/cr ratios.conclusion: according to high prevalence of hypercalciuria in this survey, it is recommended to evaluate the vitamin d level in infants and use proper amount of supplemented vitamin d. it seems that 200 iu/daily could be used in infants in our area.