Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome in Childhood; A Rare Clinical Entity

Referring to synovitis, acne, pustulosis, hyperostosis and osteitis; sapho syndrome is defined as a chronic, relapsing rheumatologic disease of uncertain etiology characterized by distinct osteoarticular and cutaneous manifestations. there have been recent reports of chronic recurrent multifocal osteomyelitis (crmo) occurring in adults and sapho syndrome occurring in children whereas just the vice-versa is normally expected. herein, we would like to emphasize a rare form of sapho syndrome in terms of age and the localization of the disease.