Absence of Association between -1131T>C Polymorphism in the Apolipoprotein APOA5 Gene and Pediatric Metabolic Syndrome

Objective: in the present study, we evaluated the association of rs662799 variant of the apoa5 gene with metabolic syndrome (mets) in a sample of children and adolescents from isfahan. methods: this case control study comprised 50 cases of mets and 50 controls. mismatched polymerase chain reaction–restriction fragment length polymorphism (mpcr-rflp) was used to genotype -1131t>c polymorphism. findings: no significant association was documented for apoa5 genotypes with the measured laboratory parameters for cc, ct, and tt genotypes in the two groups studied. by logistic regression using a dominant model, the odds ratio (95% confidence interval0 for the mets was 0.38 (0.139–1.0350 and 0.29 (0.08–1.071 for the unadjusted and adjusted models, respectively. conclusion: this study suggests that among studied children and adolescents, -1131t>c polymorphism in the apoa5 gene may not be a major contributor to the mets risk.