Therapeutic Success of the Ketogenic Diet as a Treatment Option for Epilepsy: a Meta-analysis

Objective: to systematically evaluate therapeutic success of the ketogenic diet (kd) as a treatment option for epilepsy. methods: using medline and google scholar search, we searched for studies investigating the therapeutic success of ketogenic diet for epilepsy. we estimated therapeutic success rate for ketogenic diet as a treatment option for epilepsy and its 95% cis using generic inverse variance method. findings: a total of 38 studies met the inclusion criteria. in retrospective studies, the weighted success rate of the patients who take the kd as a treatment option for epilepsy was 58.4% (95% confidence interval (95%ci)=48.7% - 69.9%) at 3 months (n=336); 42.8% (95%ci =36.3% - 50.3%) at 6 months (n=492), and 30.1% (95%ci =24.3% - 37.2%) at 12 months (n=387); in prospective studies, weighted success rate was 53.9% (95%ci 45.5% - 63.8%) at 3 months (n=474); 53.2% (95%ci =44.0% - 64.2%) at 6 months (n=321), and 55.0% (95%ci =45.9% - 65.9%) at 12 months (n=347). conclusion: this meta-analysis provides formal statistical support for the efficacy of the ketogenic diet in the treatment of epileptic patients.