serum omentin-1 levels in obese adolescents with vitamin d deficiency: a prospective cross-sectional study

Background: vitamin d deficiency is common in obese adolescents. it modulates the release of omentin 1 from adipose tissue. we believe that both vitamin d and omentin 1 affect each other in adipose tissue via inflammation. objectives: this study aimed to examine serum omentin-1 levels in obese adolescents with vitamin d (vit d) deficiency. methods: in this cross-sectional prospective study, 83 obese adolescents were included. serum 25-hydroxy vitamin d (25(oh)d) concentrations, fasting glucose, and lipid profiles of obese adolescents were studied. at the same time, blood was drawn into a separate tube to study the omentin 1 level. of the 83 obese cases, 45 with 25(oh)d concentrations below 20 ng/ml were considered as the study group, and 38 with 25(oh)d concentrations ≥ 20 ng/ml as the control group. serum omentin-1 levels were evaluated and compared. results: the average 25(oh)d value in the study and control groups was 17.14 ± 2.22 ng/ml and 45.29 ± 24.98 ng/ml, respectively. the average omentin-1 concentration of the control group was 262.5 ± 136.31 ng/ml, and the mean omentin-1 level of the study group was 113.23 ± 15.98 ng/ml. the mean omentin-1 concentrations of the study group were significantly lower compared to the control group (p = 0.0001). there was a significant and positive correlation between omentin-1 and 25(oh)d (r = 0.988, p = 0.0001). in univariate tests, linear regression analysis was carried out with 25(oh)d and omentin-1, and 25(oh)d displayed a significant positive correlation (p = 0.0001). the optimal cut-off point for the serum omentin-1 concentration was 135.01 ng/ml. no significant correlation was determined between omentin-1 and body mass index, lipid profile, glucose, and insulin variables (p > 0.05). conclusions: we showed significantly low concentrations of serum omentin-1 in obese adolescents with vitamin d deficiency. serum omentin-1 can be employed as a biomarker in obese adolescents with vitamin d deficiency.