factors associated with newborn fatality due to persistent pulmonary hypertension

Objectives: this study is designed to explore factors associated with death in newborns with persistent pulmonary hypertension (pphn). methods: the clinical data of pphn cases in the past ten years from a neonatal center in china were retrospectively collected and analyzed, and the death-related factors attributable to pphn were analyzed by binary stepwise logistic regression analysis. results: a total of 161 neonates with pphn were included in this study, with a mortality rate of 18.0% (29/161). multivariate binary logistic regression analysis indicated that cesarean delivery was negatively associated with death in infants with pphn (adjusted odds ratio [or] = 0.289, 95% confidence interval [ci] 0.104 – 0.803), while premature rupture of membranes (prom) (adjusted or = 4.032, 95% ci 1.32 - 12.32), congenital lung developmental abnormalities/congenital diaphragmatic hernia (cdh) (adjusted or = 12.65, 95% ci 1.088 – 147.068), respiratory distress syndrome (rds) (adjusted or = 4.802, 95% ci 1.512 – 15.251), inhaled nitric oxide (ino) (adjusted or = 12.377, 95% ci 3.22 – 47.576) and norepinephrine (adjusted or = 2.891, 95% ci 1.03 – 8.118) were the independent factors associated with a higher risk of death from pphn. conclusions: caesarean delivery with medical indication is an independent protective factor against death in neonates with pphn. prom, congenital lung developmental abnormalities/cdh, rds, ino, and norepinephrine were independent death-related factors in neonates with pphn.